Curated and hosted by Don Michael Mendoza and Regie Cabico, La-Ti-Do made its debut to a full house in Washington, DC on January 23, 2012 at The Black Fox Lounge in Dupont Circle. Since then, La-Ti-Do became DC's premiere musical theatre cabaret and spoken word series to serve the artistic community on a weekly basis. On June 9, 2013, the show then opened a touring chapter in New York City and continues to do so on a select basis and made a special appearance at Feinstein’s/54 Below. In 2016, La-Ti-Do became a program of a parent company: Winter's Lane Productions under the direction of Founder/Artistic Director Anya Randall Nebel.

Past musical performers range from Broadway veterans, Helen Hayes Award honorees to internationally recognized spoken word artists. Some notable alumni include Apollo Link, Jose Llana, Nova Y. Payton, Nicholas Rodriguez, Dorea Schmidt, Emily Zickler, Sonya Renee Taylor, Adele Hampton, Vijai Nathan, Sophia Walker, along with the national touring casts of The Sound of Music and The King and I.